Laboratory of Bioengineering


Victor Bulgakov Group leader Principal Investigator Doctor of biological sciences Corresponding Member of the Russian Academy of Sciences
Galina Veremeichik Senior Researcher Candidate of biological sciences
Tatiana Rusapetova Senior Researcher Candidate of biological sciences
Olga Koren Leading Engineer Candidate of biological sciences
Galina Tchernoded Leading Engineer
Eugeniya Brodovskaya Engineer
Anastasiya Khopta Postgraduate
Yuliya Konnova Senior Laboratory Assistant

Selected publications


2025 - Artificial microRNA delivery and gene silencing via extracellular vesicles derived from molecularly modified tobacco Shkryl Y., Tsydeneshieva Z., Gorpenchenko T., Kazarin V., Kudinova O., Bulgakov V., Yugay Y. Protoplasma 2025 DOI: 10.1007/s00709-025-02130-5
2025 - Functional analysis of naturally integrated rol genes in sweet potato via CRISPR/Cas9 genome editing Shkryl Y., Yaroshenko Y., Grigorchuk V., Bulgakov V., Yugay Y. Plants (Basel) 2025; 14(24): 3708 DOI: 10.3390/plants14243708
2025 - What can CDPK provide as a bioengineering tool? Veremeichik G.N., Tikhonova O.A., Brodovskaya E.V. Journal of Crop Science and Biotechnology 2025; 28: 727–750 DOI: 10.1007/s12892-025-00319-x
2025 - Update on the role of different lighting parameters in the regulation of secondary metabolism in Lithospermum erythrorhizon Sieb. et Zucc. calli Veremeichik G.N., Silantieva S.A., Grigorchuk V.P., Tikhonova O.A., Brodovskaya E.V., Subbotin E.P., Tchernoded G.K., Fedoreyev S.A., Mishchenko N.P., Vasileva E.A., Khopta A.A., Kozhanov S.O., Sibirev A.S., Kulchin Y.N., Bulgakov V.P. Plant Cell, Tissue and Organ Culture 2025; 163: 74 DOI: 10.1007/s11240-025-03280-3
2025 - Calcium-dependent regulation of anthraquinone biosynthesis by the sweet potato Ib-rolb/C gene in Rubia cordifolia callus cultures Shkryl Yu., Grishchenko O., Vasileva E., Mishchenko N., Vasyutkina E., Alaverdov E., Kudinova O., Tchernoded G., Fialko A., Tsydeneshieva Zh., Sorokina M., Yaroshenko Yu., Degtyarenko A., Fedoreyev S., Bulgakov V., Yugay Yu. Phytochemistry 2025; 242: 114710 DOI: 10.1016/j.phytochem.2025.114710
2025 - Heterologous expression of marine bacterial alkaline phosphatase enhances abiotic stress tolerance and metabolic adaptation in tobacco Yugay Yu., Kudinova O., Vasyutkina E., Adedibu P., Rudenko D., Alaverdov E., Rusapetova T., Fialko A., Degtyareva V., Bulgakov V., Balabanova L., Shkryl Yu. Journal of Plant Growth Regulation 2025; 44: 6217–6232 DOI: 10.1007/s00344-025-11824-2
2025 - Differential Modulation of Brassinosteroid and Ethylene Signalling Systems by Native and Constitutively Active Forms of the AtCPK1 Gene in Transgenic Tobacco Plants Under Heat Stress Tikhonova O.A., Grigorchuk V.P., Brodovskaya E.V., Veremeichik G.N. Plants (Basel) 2025; 14(7): 1032 DOI: 10.3390/plants14071032
2025 - Diferential regulation of cafeoylquinic acid production in Cynara cardunculus var. altilis DC calli by modulating qualitative and quantitative LED‑lighting parameters Veremeichik G.N., Silantieva S.A., Grigorchuk V.P., Tikhonova O.A., Brodovskaya E.V., Subbotin E.P., Tchernoded G.K., Yaroshenko Y.I., Kozhanov S.O., Sibirev A.V., Kulchin Y.N., Bulgakov V.P. Plant Biotechnology Reports 2025; 19: 815-825 DOI: 10.1007/s11816-025-01005-8
2025 - A naturally integrated RolD-like gene in sweet potato mediates stress-responsive pathways Yugay Y., Rusapetova T., Vasyutkina E., Sorokina M., Grigorchuk V., Degtyareva V., Rudenko D., Alaverdov E., Bulgakov V., Shkryl Y. Plant Physiology and Biochemistry 2025; 223: 109875 DOI: 10.1016/j.plaphy.2025.109875
2025 - Overexpression of the constitutively-active AtCPK1 mutant in tobacco plants confers cold and heat tolerance, possibly through modulating abscisic acid and salicylic acid signalling Veremeichik G.N., Tikhonova O.A., Grigorchuk V.P., Silantieva S.A., Brodovskaya E.V., Bulgakov D.V., Bulgakov V.P. Journal of Plant Physiology 2025; 304: 154413 DOI: 10.1016/j.jplph.2024.154413
2024 - Agropine‑type rolA modulates ROS homeostasis in an auxin‑dependent manner in rolA‑expressing cell cultures of Rubia cordifolia L. Veremeichik G.N., Solomatina T.O., Khopta A.A., Brodovskaya E.V., Gorpenchenko T.Yu., Grigorchuk V.P., Bulgakov D.V., Bulgakov V.P. Planta 2024; 261: 20 DOI: 10.1007/s00425-024-04597-7
2024 - The Improvement in the Growth and Biosynthesis of Polyphenols in Ocimum basilicum L. Plants Through Simultaneous Modulation of Light Conditions and Soil Supplementation Veremeichik G.N., Grigorchuk V.P., Subbotin E.P., Kozhanov S.O., Tikhonova O.A., Brodovskaya E.V., Silantieva S.A., Subbotina N.I., Yaroshenko Yu.L., Kulchin Yu.N., Bulgakov V.P. Horticulturae 2024; 10(12): 1295 DOI: 10.3390/horticulturae10121295
2024 - Artificial monochromatic red and green light induces the biosynthesis of rosmarinic acid in long-term cultured calli of Mertensia maritima (L.) Veremeichik G.N., Silantieva S.A., Grigorchuk V.P., Brodovskaya E.V., Subbotin E.P., Tchernoded G.K., Tikhonova O.A., Bulgakov V.P., Kulchin Y.N. Plant Cell, Tissue and Organ Culture 2024; 159: 67 DOI: 10.1007/s11240-024-02926-y
2024 - Expression of the LlBANMT Gene from Sea Lavender Leads to the Accumulation of β-alanine Betaine and Enhanced Stress Resilience in Transgenic Tobacco Plants Degtyarenko A., Grigorchuk V., Sorokina M., Yugay Y., Fialko A., Grishchenko O., Vasyutkina E., Kudinova O., Tsydeneshieva Z., Bulgakov V., Shkryl Y. Journal of Plant Growth Regulation 2024 DOI: 10.1007/s00344-024-11526-1
2024 - Exosome-like Nanoparticles, High in Trans-δ-Viniferin Derivatives, Produced from Grape Cell Cultures: Preparation, Characterization, and Anticancer Properties Shkryl Yu., Tsydeneshieva Zh., Menchinskaya E., Rusapetova T., Grishchenko O., Mironova A., Bulgakov D., Gorpenchenko T., Kazarin V., Tchernoded G., Bulgakov V., Aminin D., Yugay Yu. Biomedicines 2024; 12(9): 2142 DOI: 10.3390/biomedicines12092142
2024 - Salicylic acid and jasmonic acid biosynthetic pathways are simultaneously activated in transgenic Arabidopsis expressing the rolB/C gene from Ipomoea batatas Shkryl Y.N., Vasyutkina E.A., Gorpenchenko T.V., Mironova A.A., Rusapetova T.V., Velansky P.V., Bulgakov V.P., Yugay Y.A. Plant Physiology and Biochemistry 2024; 208: 108521 DOI: 10.1016/j.plaphy.2024.108521
2024 - Involvement of epigenetic factors in flavonoid accumulation during plant cold adaptation Bulgakov V.P., Fialko A.V., Yugay Y.A. Plant Physiology and Biochemistry 2024; 216: 109096 DOI: 10.1016/j.plaphy.2024.109096
2024 - Chromatin modifications and memory in regulation of stress-related polyphenols: finding new ways to control flavonoid biosynthesis Bulgakov V.P. Critical Reviews in Biotechnology 2024: 2336529 DOI: 10.1080/07388551.2024.2336529
2023 - Influence of Growth Regulators and Different Spectra of Monochromatic Radiation on the Growth and Biosynthetic Characteristics of Callus Culture of Ipomoea batatas (L.) Lam. Yugay Yu.A., Grishchenko O.V., Vasyutkina E.A., Grigorchuk V.P., Chukhlomina E.N., Tsydeneshieva Zh.L., Kudinova O.D., Yaroshenko Yu.L., Degtyarenko A.I., Subbotin E.P., Bulgakov V.P., Kulchin Yu.N., Shkryl Yu.N. Russian Journal of Plant Physiology 2023; 70: 181 DOI: 10.1134/S1021443723603105
2023 - Accumulation of Polyphenols and Naphthoquinones in Morphogenic Cultures of Two Drosera Species Morshneva A.V., Khandy M.T., Grigorchuk V.P., Chernoded G.K., Gorpenchenko T.Yu. Russian Journal of Plant Physiology 2023; 70: 175 DOI: 10.1134/S1021443723603075
2023 - HPLC-MS Analysis of Ginsenosides in Morphogenic Cell Cultures of Ginseng (Panax ginseng C.A. Meyer) Gorpenchenko T.Yu., Grigorchuk V.P., Makhankov V.V., Kochkin D.V., Vologzhanina Yu.V., Khandy M.T., Chernoded G.K., Zhuravlev Yu.N. Russian Journal of Plant Physiology 2023; 70: 172 DOI: 10.1134/S1021443723603087
2023 - Isolation and Characterization of Extracellular Vesicles from Arabidopsis thaliana Cell Culture and Investigation of the Specificities of Their Biogenesis Yugay Y., Tsydeneshieva Z., Rusapetova T., Grischenko O., Mironova A., Bulgakov D., Silant’ev V., Tchernoded G., Bulgakov V., Shkryl Y. Plants (Basel) 2023; 12(20): 3604 DOI: 10.3390/plants12203604
2023 - Biosynthesis of functional silver nanoparticles using callus and hairy root cultures of Aristolochia manshuriensis Yugay Y.A., Sorokina M.R., Grigorchuk V.P., Rusapetova T.V., Silant’ev V.E., Egorova A.E., Adedibu P.A., Kudinova O.D., Vasyutkina E.A., Ivanov V.V., Karabtsov A.A., Mashtalyar D.V., Degtyarenko A.I., Grishchenko O.V., Kumeiko V.V., Bulgakov V.P., Shkryl Y.N. Journal of Functional Biomaterials 2023; 14(9): 451 DOI: 10.3390/jfb14090451
2023 - Auxin-dependent regulation of growth via rolB-induced modulation of the ROS metabolism in the long-term cultivated pRiA4-transformed Rubia cordifolia L. calli Veremeichik G.N., Gorpenchenko T.Y., Rusapetova T.V., Brodovskaya E.V., Tchernoded G.K., Bulgakov D.V., Shkryl Y.N., Bulgakov V.P. Plant Physiology and Biochemistry 2023; 202: 107932 DOI: 10.1016/j.plaphy.2023.107932
2023 - Proteomic Analysis of ProteinsRelated to Defense Responses in Arabidopsis Plants Transformed with the rolB Oncogene Vereshchagina Y.V., Mironova A.A., Bulgakov D.V., Bulgakov V.P. International Journal of Molecular Sciences 2023; 24(3): 1880 DOI: 10.3390/ijms24031880
2023 - Proteome-Level Investigation of Vitis amurensis Calli Transformed with a Constitutively Active, Ca2+-Independent Form of the Arabidopsis AtCPK1 Gene Veremeichik G.N., Bulgakov D.V., Konnova Yu.A., Brodovskaya E.V., Grigorchuk V.P., Bulgakov V.P. International Journal of Molecular Sciences 2023; 24(17): 13184 DOI: 10.3390/ijms241713184
2023 - In the interkingdom horizontal gene transfer, the small rolA gene is a big mystery Veremeichik G.N., Bulgakov D.V., Solomatina T.O., Makhazen D.S. Applied Microbiology and Biotechnology 2023; 107: 2097–2109 DOI: 10.1007/s00253-023-12454-y
2023 - Enhanced Production of Nitrogenated Metabolites with Anticancer Potential in Aristolochia manshuriensis Hairy Root Cultures Shkryl Y.N., Tchernoded G.K., Yugay Y.A., Grigorchuk V.P., Sorokina M.R., Gorpenchenko T.Y., Kudinova O.D., Degtyarenko A.I., Onishchenko M.S., Shved N.A., Kumeiko V.V., Bulgakov V.P. International Journal of Molecular Sciences 2023; 24(14): 11240 DOI: 10.3390/ijms241411240
2023 - Suppression of the HOS1 Gene Affects the Level of ROS Depending on Light and Cold Gorpenchenko T.Y., Veremeichik G.N., Shkryl Y.N., Yugay Y.A., Grigorchuk V.P., Bulgakov D.V., Rusapetova T.V., Vereshchagina Y.V., Mironova A.A., Subbotin E.P., Kulchin Y.N., Bulgakov V.P. Life 2023; 13(2): 524 DOI: 10.3390/life13020524
2023 - High production of flavonols and anthocyanins in Eruca sativa (Mill) Thell plants at high artificial LED light intensities Veremeichik G.N., Grigorchuk V.P., Makhazen D.S., Subbotin E.P., Kholin A.S., Subbotina N.I., Bulgakov D.V., Kulchin Y.N., Bulgakov V.P. Food Chemistry 2023; 408: 135216 DOI: 10.1016/j.foodchem.2022.135216
2022 - Monochromatic LEDs Effect on Rocket (Eruca sativa. Mill.) Morphogenesis and Productivity Kulchin Yu.N., Bulgakov V.P., Subbotin E.P., Kholin A.S., Subbotina N.I. Bulletin of the Russian Academy of Sciences: Physics 2022; (86): 114-118 DOI: 10.3103/S1062873822700502
2022 - Cold stress tolerance of Nicotiana tabacumplants transformed with the AtCPK1 gene of Arabidopsis thaliana Veremeichik G.N. , Tikhonova O.A. Vestnik of the Far East Branch of the Russian academy of sciences 2022; (5): 17-24 DOI: 10.37102/0869-7698_2022_225_05_2 IN RUSSIAN
2022 - Effect of Stress Signals and Ib-rolB/C Overexpression on Secondary Metabolite Biosynthesis in Cell Cultures of Ipomoea batatas Vasyutkina E.A., Yugay Y.A., Grigorchuk V.P., Grishchenko O.V., Sorokina M.R., Yaroshenko Y.L., Kudinova O.D., Stepochkina V.D., Bulgakov V.P., Shkryl Y.N. International Journal of Molecular Sciences 2022; 23(23): 15100 DOI: 10.3390/ijms232315100
2022 - Callus Culture of Scorzonera radiata as a New, Highly Productive and Stable Source of Caffeoylquinic Acids. Grishchenko O.V., Grigorchuk V.P., Tchernoded G.K., Koren O.G., Bulgakov V.P. Molecules 2022; 27(7989) DOI: 10.3390/molecules27227989
2022 - ABA-Dependent Regulation of Calcium-Dependent Protein Kinase Gene GmCDPK5 in Cultivated and Wild Soybeans Veremeichik G.N., Brodovskaya E.V., Grigorchuk V.P., Butovets E.S., Lukyanchuk L.M., Bulgakov V.P. Life 2022; 12(10): 1576 DOI: 10.3390/life12101576
2022 - EXOSOMAL PLANT NANOPARTICLES: PROPERTIES AND APPLICATIONS IN BIOMEDICINE Tsydeneshieva Z.L., Degtyarenko A.I., Yugay Yu.A., Rusapetova T.V., Shkryl Yu.N. Vestnik of the Far East Branch of the Russian academy of sciences 2022; (5): 25-44 DOI: 10.37102/0869-7698_2022_225_05_3 IN RUSSIAN
2022 - The RolB/RolC homolog from sweet potato promotes early flowering and triggers premature leaf senescence in transgenic Arabidopsis thaliana plants Shkryl Y., Yugay Y., Vasyutkina E., Chukhlomina E., Rusapetova T., Bulgakov V. Plant Physiology and Biochemistry 2022; 193: 50-60 DOI: 10.1016/j.plaphy.2022.10.018
2022 - Histological Structure and Composition of Secondary Metabolites in Cell Culture of Drosera rotundifolia L. Khandy M.T., Chernoded G.K., Grigorchuk V.P., Vereshchagina Yu.V., Morshneva A.V., Gorpenchenko T.Yu. Russian Journal of Plant Physiology 2022; 69(5): 451-461 DOI: 10.1134/S1021443722050090
2022 - Plant Exosomal Vesicles: Perspective Information Nanocarriers in Biomedicine Shkryl Y., Tsydeneshieva Z., Degtyarenko A., Yugay Y., Balabanova L., Rusapetova T., Bulgakov V. Applied Sciences-Bazel 2022; 12(16): 8262 DOI: 10.3390/app12168262
2022 - Transcriptional regulation of enzymes involved in ROS metabolism and abiotic stress resistance in rolC-transformed cell cultures Shkryl Yu., Veremeichik G., Avramenko T., Gorpenchenko T., Tchernoded G., Bulgakov V. Plant Growth Regulation 2022; 97(3): 485-497 DOI: 10.1007/s10725-022-00812-1
2022 - Overexpression of the A4‑rolB gene from the pRiA4 of Rhizobium rhizogenes modulates hormones homeostasis and leads to an increase of favonoid accumulation and drought tolerance in Arabidopsis thaliana transgenic plants Veremeichik G.N., Shkryl Yu.N., Rusapetova T.V., Silantieva S.A., Grigorchuk V.P., Velansky P.V., Brodovskaya E.V., Konnova Y.A., Khopta A.A., Bulgakov D.V., Bulgakov V.P. Planta 2022; 256: 8 DOI: 10.1007/s00425-022-03927-x
2022 - Engineered fungus Thermothelomyces thermophilus producing plant storage proteins. Balabanova L., Seitkalieva A., Yugay Y., Rusapetova T., Slepchenko L., Podvolotskaya A., Yatsunskaya M., Vasyutkina E., Son O., Tekutyeva L., Shkryl Y. Journal of Fungi 2022; 8(2): 119 DOI: 10.3390/jof8020119
2022 - Basic Protein Modules Combining Abscisic Acid and Light Signaling in Arabidopsis Bulgakov V.P., Koren O.G. Frontiers in Plant Science 2022; 12: 808960 DOI: 10.3389/fpls.2021.808960
2022 - New Applied Problems in the Theory of Acyclic Digraphs Tsitsiashvili G., Bulgakov V. Mathematics 2022; 10(1): 45 DOI: 10.3390/math10010045
2022 - Growth of micropropagated Solanum tuberosum L. plantlets under artificial solar spectrum and different mono- and polychromatic LED lights Grishchenko O.V., Subbotin E.P., Gafitskaya I.V., Vereshchagina Y.V., Burkovskaya E.V., Khrolenko Y.A., Grigorchuk V.P., Nakonechnaya O.V., Bulgakov V.P., Kulchin Y.N. Horticultural Plant Journal 2022; 8(2): 205-214 DOI: 10.1016/j.hpj.2021.04.007
2021 - Biosynthesis and cytotoxic properties of Ag, Au, and bimetallic nanoparticles synthesized using Lithospermum erythrorhizon callus culture extract Shkryl Y., Rusapetova T., Yugay Y., Egorova A., Silant’ev V., Grigorchuk V., Karabtsov A., Timofeeva Y., Vasyutkina E., Kudinova O., Ivanov V., Kumeiko V., Bulgakov V. International Journal of Molecular Sciences 2021; 22(17): 9305 DOI: 10.3390/ijms22179305
2021 - Biomimetic synthesis of functional silver nanoparticles using hairy roots of Panax ginseng for wheat pathogenic fungi treatment Yugay Y., Rusapetova T., Mashtalyar D., Grigorchuk V., Vasyutkina E., Kudinova O., Zenkina K., Trifuntova I., Karabtsov A., Ivanov V., Aseeva T., Bulgakov V., Shkryl Y. Colloids and Surfaces B: Biointerfaces 2021; 207: 112031 DOI: 10.1016/j.colsurfb.2021.112031
2021 - Inhibition of the JAZ1 gene causes activation of camalexin biosynthesis in Arabidopsis callus cultures Makhazen D.S., Veremeichik G.N., Shkryl Y.N., Tchernoded G.K., Grigorchuk V.P., Bulgakov V.P. Journal of Biotechnology 2021; 342: 102-113 DOI: 10.1016/j.jbiotec.2021.10.012
2021 - PHOTONIC REGULATION OF BIOSYNTHESIS OF SECONDARY METABOLITES IN ROCKET ERUCA SATIVA Kulchin YU.N., Bulgakov V.P., Subbotin E.P., Goltsova D.O., Kholin A.S., Lyakhova L.P., Subbotina N.I., Gafitskaya I.V., Grigorchuk V.P., Burkovskaya E.V., Khrolenko YU.A., Orlovskaya I.YU., Nakonechnaya O.V. Vestnik of the Far East Branch of the Russian academy of sciences 2021; (4): 87-98 DOI: 10.37102/0869-7698_2021_218_04_10 IN RUSSIAN
2021 - RNA inhibition of the JAZ9 gene increases the production of resveratrol in grape cell cultures Makhazen D.S., Veremeichik G.N., Shkryl Y.N., Grigorchuk V.P., Tchernoded G.K., Degtyarenko A.I., Bulgakov V.P. Plant Cell, Tissue and Organ Culture 2021; 147: 611–618 DOI: 10.1007/s11240-021-02152-w
2021 - Managing activity and Ca²⁺ dependence through mutation in the Junction of the AtCPK1 coordinates the salt tolerance in transgenic tobacco plants Veremeichik G.N., Shkryl Y.N., Silantieva S.A., Gorpenchenko T.Y., Brodovskaya E.V., Yatsunskaya M.S., Bulgakov V.P. Plant Physiology and Biochemistry 2021; 165: 104-113 DOI: 10.1016/j.plaphy.2021.05.026
2021 - A Brief Overview of Potential Treatments for Viral Diseases Using Natural Plant Compounds: The Case of SARS-Cov Rambod A., Hazandy A.-H., Sytar O., Ramin A., Bezerra de Almeida Jr.E., Surender K.S., Bulgakov V.P., Arroo R.J.R., Malik S. Molecules 2021; 26(13): 3868 DOI: 10.3390/molecules26133868
2021 - CRISPR/Cas9-Mediated Knockout of HOS1 Reveals Its Role in the Regulation of Secondary Metabolism in Arabidopsis thaliana Shkryl Y.N., Yugay Y.A., Avramenko T.V., Grigorchuk V.P., Gorpenchenko T.Y., Grischenko O.V., Bulgakov V.P. Plants (Basel) 2021; 10(1): 104 DOI: 10.3390/plants10010104
2021 - Inactivation of the auto-inhibitory domain in Arabidopsis AtCPK1 leads to increased salt, cold and heat tolerance in the AtCPK1-transformed Rubia cordifolia L cell cultures Veremeichik G.N., Shkryl Y.N., Gorpenchenko T.Y., Silantieva S.A., Avramenko T.V., Brodovskaya E.V., Bulgakov V.P. Plant Physiology and Biochemistry 2021; 159: 372-382 DOI: 10.1016/j.plaphy.2020.12.031
2021 - Optimization of the transient Agrobacterium-mediated transformation of Panax ginseng shoots and its use to change the profile of ginsenoside production Degtyarenko A.I., Gorpenchenko T.Y., Grigorchuk V.P., Bulgakov V.P., Shkryl Y.N. Plant Cell, Tissue and Organ Culture 2021; 146: 357–373 DOI: 10.1007/s11240-021-02075-6
2021 - Poor fruit set due to lack of pollinators in Aristolochia manshuriensis (Aristolochiaceae) Nakonechnaya O.V., Koren O.G., Sidorenko V.S., Shabalin S.A., Markova T.O., Kalachev A.V. Plant Ecology and Evolution 2021; 154(1): 39–48 DOI: 10.5091/plecevo.2021.1747
2021 - Effect of LED lighting on morphogenesis and content of ascorbic acid, P, K, and Ca in Eruca sativa plants Nakonechnaya O.V., Grishchenko O.V., Khrolenko Yu.A., Bulgakov V.P., Burkovskaya E.V., Grigorchuk V.P., Prokuda N.A., Kholin A.S., Gafitskaya I.V., Mikheeva A.V., Orlovskaya I.Yu., Burdukovskii M.L., Subbotin E.P., Kul’chin Yu.N. Russian Journal of Plant Physiology 2021; 68(2): 356–366 DOI: 10.1134/S1021443721020138
2021 - In vitro potato plantlet development under different polychromatic LED spectra and dynamic illumination Nakonechnaya O.V., Subbotin E.P., Grishchenko O.V., Gafitskaya I.V., Orlovskaya I.Yu., Kholin A.S., Goltsova D.O., Subbotina N.I., Bulgakov V.P., Kulchin Yu.N. Botanica Pacifica: a journal of plant science and conservation 2021; 10(1): 69–74 DOI: 10.17581/bp.2021.10102
2020 - PATHOGEN RESISTANCE OF CULTIVATED AND WILD SOYBEAN UNDER ARTIFICIAL INFECTION WITH THE PATHOGEN SEPTORIA GLYCINES HEMMI Veremeichik G.N., Brodovskaya E.V., Butovets E.S., Lukyanchuk L.M. Far East Agrarian Bulletin 2020; 4(56): 5-12 DOI: 10.24411/1999-6837-2020-14041 IN RUSSIAN
2020 - Isoflavonoid biosynthesis in cultivated and wild soybeans grown in the field under adverse climate conditions Veremeichik G.N., GrigorchukV.P., Butovets E.S., Lukyanchuk L.M., Brodovskaya E.V., Bulgakov D.V., Bulgakov V.P. Food Chemistry 2020 DOI: 10.1016/j.foodchem.2020.128292
2020 - Synthesis of bioactive silver nanoparticles using alginate, fucoidan and laminaran from brown algae as a reducing and stabilizing agent Yugay Y.A., Usoltseva R.V., Silant'ev V.E., Egorova A.E., Karabtsov A.A., Kumeiko V.V., Ermakova S.P., Bulgakov V.P., Shkryl Y.N. Carbohydrate Polymers 2020; 245: 116547 DOI: 10.1016/j.carbpol.2020.116547
2020 - Polycondensation of Silicon and Titanium Dioxide Precursors on Natural and Synthetic Polymeric Matrices Shkryl Y.N., Degtyarenko A.I., Gorpenchenko T.Y., Avramenko T.V., Bulgakov V.P. Russian Journal of Bioorganic Chemistry 2020; 46(5): 866-868 DOI: 10.1134/S1068162020050210
2020 - Linking Brassinosteroid and ABA Signaling in the Context of Stress Acclimation Bulgakov V.P, Avramenko T.V. International Journal of Molecular Sciences 2020; 21(14): 5108 DOI: 10.3390/ijms21145108
2020 - Biomanufacturing of nanocrystals using protein biocatalysts Avramenko T.V., Shkryl Yu.N., Veremeichik G.N., Bulgakov V.P. Journal of Nanoparticle Research 2020; 22(5): 110 DOI: 10.1007/s11051-020-04841-7
2020 - Differential expression of calcium-dependent protein kinase genes (CDPK1–14) in Rubia cordifolia callus cultures transformed with the rolB and rolC genes Shkryl Y.N., Veremeichik G.N., Silantieva S.A., Bulgakov V.P. Plant Gene 2020; 21: 100215 DOI: 10.1016/j.plgene.2019.100215
2019 - INTERACTION OF YERSINIA PSEUDOTUBERCULOSIS WITH CALLUSES PANAX GINSENG C.A. MEY Timchenko N.F., Eliseykina M.G., Chernoded G.K., Grishchenko O.G., Bulgakov V.P. Health. Medical ecology. Science 2019; 79(3): 4-7 DOI: 10.5281/zenodo.3559604 IN RUSSIAN
2019 - IN VITRO COMPARATIVE ANALYSIS OF THE ISOFLAVONE CONTENT AND RESISTANCE TO ABIOTIC STRESS IN CULTURAL AND WILD SOYBEAN Veremeichik G.N., Brodovskaya E.V., Grigorchuk V.P., Burundukova O.L., Butovetz E.S., Lukyanchuk L.M., Vasina E.A. Far East Agrarian Bulletin 2019; (52): 16-23 DOI: 10.24411/1999-6837-2019-14047 IN RUSSIAN
2019 - Coordination of ABA and Chaperone Signaling in Plant Stress Responses Bulgakov V.P., Wu H.C., Jinn T.L. Trends in Plant Science 2019; 24(7): 636-651 DOI: 10.1016/j.tplants.2019.04.004
2019 - Extra Purified Exosomes from Human Placenta Contain An Unpredictable Small Number of Different Major Proteins. Burkova E.E., Grigor'eva A.E., Bulgakov D.V., Dmitrenok P.S., Vlassov V.V., Ryabchikova E.I., Sedykh S.E., Nevinsky G.A. International Journal of Molecular Sciences 2019; 20(10): 2434 DOI: 10.3390/ijms20102434
2019 - Activation of anthraquinone biosynthesis in long-cultured callus culture of Rubia cordifolia transformed with the rolA plant oncogene Veremeichik G.N., Bulgakov V.P., Shkryl Y.N., Silantieva S.A., Makhazen D.S., Tchernoded G.K., Mischenko N.P., Fedoreyev S.A., Vasileva E.A. Journal of Biotechnology 2019; 306: 38-46 DOI: 10.1016/j.jbiotec.2019.09.007
2019 - Tempo-spatial pattern of stepharine accumulation in Stephania glabra morphogenic tissues Gorpenchenko T.Y.; Grigorchuk V.P.; Bulgakov D.V.; Tchernoded G.K.; Bulgakov V.P. International Journal of Molecular Sciences 2019; 20(4): 808 DOI: 10.3390/ijms20040808
2019 - Development of host strains and vector system for an efficient genetic transformation of filamentous fungi Balabanova L.A., Shkryl Y.N., Slepchenko L.V., Yugay Y.A., Gorpenchenko T.Y., Kirichuk N.N., Khudyakova Y.V., Bakunina I.Y., Podvolotskaya A.B., Bulgakov V.P., Seitkalieva A.V., Son O.M., Tekutyeva L.A. Plasmid 2019; 101 DOI: 10.1016/j.plasmid.2018.11.002
2019 - Increase in isoflavonoid content in Glycine max cells transformed by the constitutively active Ca²⁺ independent form of the AtCPK1 gene Veremeichik G.N., Grigorchuk V.P., Silanteva S.A., Shkryl Y.N., Bulgakov D.V., Brodovskaya E.V., Bulgakov V.P. Phytochemistry 2019; 157 DOI: 10.1016/j.phytochem.2018.10.023
2018 - Biomimetic synthesis of nanosized silica structures on a substrate with silicatein Shkryl Y.N., Veremeichik G.N., Avramenko T.V., Bulgakov V.P., Semiletova I.V., Shchipunov Y.A., Nepomnyaschiy A.V., Voznesenskiy S.S., Kovalchuk S.N., Kozhemyako V.B. Russian Journal of Bioorganic Chemistry 2018; 44(4): 469-471 DOI: 10.1134/S1068162018040180
2018 - Extremely stable high molecular mass soluble multiprotein complex from eggs of sea urchin Strongylocentrotus intermedius with phosphatase activity. Soboleva S.E., Burkova E.E., Dmitrenok P.S., Bulgakov D.V., Menzorova N.I., Buneva V.N., Nevinsky G.A. Journal of Molecular Recognition 2018 DOI: 10.1002/jmr.2753
2018 - Identification of Major Proteins of a Very Stable High Molecular Mass Multi-Protein Complex of Human Placental Tissue Possessing Nine Different Catalytic Activities Burkova E.E., Dmitrenok P.S., Bulgakov D.V., Ermakov E.A., Buneva V.N., Soboleva S.E., Nevinsky G.A. Biochemistry and Analytical Biochemistry 2018 DOI: 10.4172/2161-1009.1000351
2018 - Exosomes from Human Placenta Purified by Affinity Chromatography on Sepharose Bearing Immobilized Antibodies Against CD81 Tetraspanin ContainMany Peptides and Small Proteins Burkova E.E., Dmitrenok P.S., Bulgakov D.V., Vlassov V.V., Ryabchikova E.I., Nevinsky G.A. IUBMB Life 2018: 12 DOI: 10.1002/iub.1928
2018 - Pectin Methylesterases: Cell Wall Remodeling Proteins Are Required for Plant Response to Heat Stress. Wu H.C., Bulgakov V.P., Jinn T.L. Frontiers in Plant Science 2018 DOI: 10.3389/fpls.2018.01612
2018 - Plant morphogenesis under different light intensity Kulchin Yu.N., Nakonechnaya O.V., Gafitskaya I.V., Grishchenko O.V., Epifanova T.Yu., Orlovskaya I.Y., Zhuravlev Yu.N., Subbotin E.P. Defect and Diffusion Forum 2018; 386: 201-206 DOI: 10.4028/www.scientific.net/DDF.386.201
2018 - State of antioxidant systems and ginsenoside contents in the leaves of Panax ginseng in a natural habitat and an artificial plantation Shkryl Y.N., Veremeychik G.N., Avramenko T.V., Makhankov V.V., Bulgakov D.V., Yugay Y., Burundukova O.L., Muzarok T.I., Bulgakov V.P., Zhuravlev Y.N. Acta Physiologiae Plantarum 2018; 40: 124 DOI: 10.1007/s11738-018-2699-3
2018 - Construction of Minimal Connected Network with Proteins Affected By Expression of the Rol B Plant Oncogene. Tsitsiashvili G.Sh., Bulgakov V.P., Losev A.S. Biostatistics and Biometrics Open Access Journal 2018; 4(4): 555644 DOI: 10.19080/BBOAJ.2018.04.555644
2018 - The rolB plant oncogene affects multiple signaling protein modules related to hormone signaling and plant defense Bulgakov V.P., Vereshchagina Y.V., Bulgakov D.V., Veremeichik G.N., Shkryl Y.N. Scientific Reports 2018; 8(1) DOI: 10.1038/s41598-018-20694-6
2018 - Green synthesis of silver nanoparticles using transgenic Nicotiana tabacum callus culture expressing silicatein gene from marine sponge Latrunculia oparinae Shkryl Y.N., Veremeichik G.N., Kamenev D.G., Gorpenchenko T.Y., Yugay Y.A., Mashtalyar D.V., Nepomnyaschiy A.V., Avramenko T.V., Karabtsov A.A., Ivanov V.V., Bulgakov V.P., Gnedenkov S.V., Kulchin Y.N., Zhuravlev Y.N. Artificial Cells, Nanomedicine, and Biotechnology 2018; 46(8): 1646-1658 DOI: 10.1080/21691401.2017.1388248
2017 - Hierarchical Classification F Directed Graph Nodes and Application to Protein networks Tsitsiashvili G.S., Bulgakov V., Losev A. Biostatistics and Biometrics Open Access Journal 2017; 1(4): 555567 DOI: 10.19080/BBOAJ.2017.01.555567
2017 - REGENERATION POTENTIAL IN VITRO OF SOYBEAN VARIETIES IN AGROBACTERIAL TRANSFORMATION Efremova O.S., Shkryl Yu.N., Veremeichik G.N. Agrarian newsletter of Primoriye 2017; (4(8)): 21-23 IN RUSSIAN
2017 - Purified horse milk exosomes contain an unpredictable small number of major proteins Sedykh S.E., Purvinis, L.V., Monogarov A.S., Burkova E.E., Grigor'eva A.E., Bulgakov D.V., Dmitrenok P.S.,Vlassov V.V., Ryabchikova E.I., Nevinsky G.A. Biochimie Open 2017; 4: 61-72 DOI: 10.1016/j.biopen.2017.02.004
2017 - Factorization of directed graph describing protein network. Tsitsiashvili G.Sh., Bulgakov V.P., Losev A.S. Applied Mathematical Sciences 2017; 11(39): 1925 - 1931 DOI: 10.12988/ams.2017.76205
2017 - A NEW APPROACH OF SECONDARY METABOLISM ACTIVATION IN PLANT CELLS BY INHIBITING THE EXPRESSION OF JAZ GENES BY RNA-INTERFERENCE Makhazen D.S. Vestnik of the Far East Branch of the Russian academy of sciences 2017; (4): 130-134 IN RUSSIAN
2017 - Anticancer Polyphenols from Cultured Plant Cells: Production and New Bioengineering Strategies. Bulgakov V.P., Vereshchagina Y.V., Veremeichik G.N. Current Medicinal Chemistry 2017 DOI: 10.2174/0929867324666170609080357
2017 - GENETIC VARIABILITY OF ASARUM SIEBOLDII (ARISTOLOCHIACEAE) IN THE POPULATION OF PRIMORSKY REGION Nakonechnaya O.V., Koren O.G. Bulletin of KrasGAU 2017; (1): 132-137 IN RUSSIAN
2017 - Induction of resveratrol biosynthesis in Vitis amurensis cells by heterologous expression of the Arabidopsis constitutively active, Ca2+-independent form of the AtCPK1 gene Veremeichik G.N., Grigorchuk V.P., Shkryl Y.N., Bulgakov D.V., Silantieva S.A., Bulgakov V.P. Process Biochemistry 2017; 54: 144-155 DOI: 10.1016/j.procbio.2016.12.026
2017 - Stepharine production in morphogenic cell cultures of Stephania glabra (ROXB.) Miers Gorpenchenko T.Y., Grigorchuk V.P., Fedoreyev S.A., Tarbeeva D.V., Tchernoded G.K., Bulgakov V.P. Plant Cell, Tissue and Organ Culture 2017; 128(1): 67-76 DOI: 10.1007/s11240-016-1083-5
2017 - Critical analysis of protein signaling networks involved in the regulation of plant secondary metabolism: focus on anthocyanins. Bulgakov V.P., Avramenko T.V., Tsitsiashvili G.Sh. Critical Reviews in Biotechnology 2017; 37(6): 685-700 DOI: 10.3109/07388551.2016.1141391
2016 - Hierarchial classification of directed graph with cyclically equivalent nodes Tsitsiashvili G.Sh., Bulgakov V.P., Losev A.S. Applied Mathematical Sciences 2016; 10(49): 2529-2536 DOI: 10.12988/ams.2016.66192
2016 - Increase of anthraquinone content in Rubia cordifolia cells transformed by native and constitutively active forms of the AtCPK1 gene. Shkryl Y.N., Veremeichik G.N., Makhazen D.S., Silantieva S.A., Mishchenko N.P., Vasileva E.A., Fedoreyev S.A., Bulgakov V.P. Plant Cell Reports 2016; 35(9): 1907-1916 DOI: 10.1007/s00299-016-2005-z
2016 - Modulation of NADPH-oxidase gene expression in rolB-transformed calli of Arabidopsis thaliana and Rubia cordifolia Veremeichik G.N., Bulgakov V.P., Shkryl Y.N. Plant Physiology and Biochemistry 2016; 105: 282-289 DOI: 10.1016/j.plaphy.2016.05.014
2016 - RolB gene-induced production of isoflavonoids in transformed Maackia amurensis cells Grishchenko O.V., Kiselev K.V., Tchernoded G.K., Fedoreyev S.A., Veselova M.V., Bulgakov V.P., Zhuravlev Y.N. Applied Microbiology and Biotechnology 2016; (17): 7479-7489 DOI: 10.1007/s00253-016-7483-y
2016 - The rolB gene activates secondary metabolism in Arabidopsis calli via selective activation of genes encoding MYB and bHLH transcription factors Bulgakov V.P., Veremeichik G.N., Grigorchuk V.P., Rybin V.G., Shkryl Y.N. Plant Physiology and Biochemistry 2016; 102: 70-79 DOI: 10.1016/j.plaphy.2016.02.015
2016 - Bioinspired enzymatic synthesis of silica nanocrystals provided by recombinant silicatein from the marine sponge Latrunculia oparinae Shkryl Y.N., Bulgakov V.P., Veremeichik G.N., Kovalchuk S.N., Kozhemyako V.B., Kamenev D.G., Semiletova I.V., Timofeeva Y.O., Shchipunov Y.A., Kulchin Y.N. Bioprocess and Biosystems Engineering 2016; 39(1): 53-58 DOI: 10.1007/s00449-015-1488-2

Group members

Victor Bulgakov

Galina Veremeichik

Tatiana Rusapetova

Olga Koren

Galina Tchernoded

Eugeniya Brodovskaya

Anastasiya Khopta

Yuliya Konnova

Selected publications