Chelomina G.N.
В издании Molecular Medical Microbiology
Год: 2024 Страницы: 3221-3234
This chapter reviews our current knowledge about genomics and transcriptomics of the Chinese liver fluke Clonorchis sinensis, a causative agent of severe hepatobiliary diseases of humans and animals. Beginning with a brief overview on the advantages and achievements of the omics approaches in modern parasitology, this chapter presents key discoveries in the field of C. sinensis genome organization including intraspecific variations, ranging from the role of codon usage, mobile genetic elements, miRNAs genes for parasite development, survival, parasite–host interactions, to host pathogenesis. This is followed by data relating to the dynamics of the transcriptome during individual development and tissue differentiation, along with the most expressed gene families and candidate drug targets for C. sinensis infection treatment and diagnostics, and finally a discussion on future directions for promising clonorchiasis research.
