Drozdov K.А., Sabutski Yu.E., Vshivkova T.S., Makarenko V.P.
В журнале European Proceedings of Social and Behavioural Sciences
Год: 2022 Том: 126 Страницы: 245-252
There is an opinion that the biological activity of chemical compounds derived from natural raw materials and that of artificially synthesized compounds (analogues of natural substances) may differ. This assumption, however, is still poorly supported by serious scientific research. In our work, we compared a chloroform solution of synthetic juglone (5-hydroxy-1,4-naphthoquinone) and a chloroform extract from a mesocarp of Manchurian walnut (Juglans mandshurica Maxim. (1856)) using the nuclear magnetic resonance (NMR) method to identify possible differences. Research has shown that synthetic and natural juglone are completely identical. This is confirmed by the coincidence of the NMR signals in the spectra of both substances. Differences were found in the content of impurities, although their content is very insignificant and does not exceed 0.1%. With a 15-fold increase in the spectrum of synthetic juglone in the range of 1.5–3.75 ppm, it was seen that the mixture under study contains water in two forms: free and bound (in salts). The presence of these signals allows us to conclude that salts are one of the main impurities in the synthetic juglone sample. The results showed that different forms of 5-hydroxy-1,4- naphthoquinone are present in the synthesized juglone and Manchurian walnut pericarp extract.
