Bioinformatics analysis of protein interaction networks: statistics, topologies, and meeting the standards of experimental biologists

Bulgakov V.P., Tsitsiashvili G.S.

В журнале Biochemistry (Moscow)

Год: 2013 Том: 78 Номер: 10 Страницы: 1098-1103

In recent years, bioinformatics analyses of protein networks have allowed researchers to obtain exceptional theoretical predictions and subsequent experimental confirmations. The current view is that protein networks are scale-free networks and have a topology analogous to that of transport networks, the Internet, and social networks. However, an alternative hypothesis exists in which protein networks and scale-free networks possess significantly different properties. In this work, we show that existing information is insufficient to describe protein networks as scale-free networks.

DOI 10.1134/S0006297913100039