Dyshlovoy S.A., Tarbeeva D., Fedoreyev S., Busenbender T., Kaune M., Veselova M., Kalinovskiy A., Hauschild J., Grigorchuk V., Kim N., Bokemeyer C., Graefen M., Gorovoy P., von Amsberg G.
В журнале Biomolecules
Год: 2020 Том: 10 Выпуск: 3 Страницы: 451
From a root bark of Lespedeza bicolor Turch we isolated two new (7 and 8) and six previously known compounds (1-6) belonging to the group of prenylated polyphenols. Their structures were elucidated using mass spectrometry, nuclear magnetic resonance and circular dichroism spectroscopy. These natural compounds selectively inhibited human drug-resistant prostate cancer in vitro. Prenylated pterocarpans 1-3 prevented the cell cycle progression of human cancer cells in S-phase. This was accompanied by a reduced expression of mRNA corresponding to several human cyclin-dependent kinases (CDKs). In contrast, compounds 4-8 induced a G1-phase cell cycle arrest without any pronounced effect on CDKs mRNA expression. Interestingly, a non-substituted hydroxy group at C-8 of ring D of the pterocarpan skeleton of compounds 1-3 seems to be important for the CDKs inhibitory activity.
