Betaine biosynthesis in a heterologous expression system based on the B12 producer Pseudomonas denitrificans

Shkryl Y., Degtyarenko A., Grigorchuk V., Balabanova L., Tekutyeva L.

В журнале E3S Web of Conferences

Год: 2020 Том: 222 ArticleID: 02047

Glycine betaine is an important donor of methyl groups in various metabolic processes of the cell and acts as an osmoprotector when exposed to various abiotic stresses in pro- and eukaryotic organisms. Moreover, exogenous application of betaine activates the production of vitamin B12 in industrial strains-producers. In this work, we have developed a new technology for microbiological betaine synthesis that can be used in biotechnology to activate B12 biosynthesis during large-scale fermentation of Pseudomonas denitrificans.

DOI 10.1051/e3sconf/202022202047