Personalized regulation of glioblastoma cancer stem cells based on biomedical technologies: From theory to experiment

Bryukhovetskiy I., Ponomarenko A., lyakhova I., Zaitsev S., Zayats Yu., Korneyko M., Eliseikina M., Mischenko P., Shevchenko V., Sharma H., Sharma A., Khotimchenko Yu.

В журнале International Journal of Molecular Medicine

Год: 2018 Том: 42 Номер: 2 Страницы: 691-702

Glioblastoma multiforme (GBM) is one of the most aggressive brain tumors. GBM represents >50% of primary tumors of the nervous system and ~20% of intracranial neoplasms. Standard treatment involves surgery, radiation and chemotherapy. However, the prognosis of GBM is usually poor, with a median survival of 15 months. Resistance of GBM to treatment can be explained by the presence of cancer stem cells (CSCs) among the GBM cell population. At present, there are no effective therapeutic strategies for the elimination of CSCs. The present review examined the nature of human GBM therapeutic resistance and attempted to systematize and put forward novel approaches for a personalized therapy of GBM that not only destroys tumor tissue, but also regulates cellular signaling and the morphogenetic properties of CSCs. The CSCs are considered to be an informationally accessible living system, and the CSC proteome should be used as a target for therapy directed at suppressing clonal selection mechanisms and CSC generation, destroying CSC hierarchy, and disrupting the interaction of CSCs with their microenvironment and extracellular matrix. These objectives can be achieved through the use of biomedical cellular products.

DOI 10.3892/ijmm.2018.3668