Zhidkov M.E., Smirnova P.A., Tryapkin O.A., Kantemirov A.V., Khudyakova Y.V., Malyarenko O.S., Ermakova S.P., Grigorchuk V.P., Kaune M., von Amsberg G., Dyshlovoy S.A.
В журнале Marine Drugs
Год: 2019 Том: 17 Номер: 9 ArticleID: 496
A simple approach toward the synthesis of the marine sponge derived pigment fascaplysin was used to obtain the marine alkaloids 3-bromofascaplysin and 3,10-dibromofascaplysin. These compounds were used for first syntheses of the alkaloids 14-bromoreticulatate and 14-bromoreticulatine. Preliminary bioassays showed that 14-bromoreticulatine has a selective antibiotic (to Pseudomonas aeruginosa) activity and reveals cytotoxicity toward human melanoma, colon, and prostate cancer cells. 3,10-Dibromofascaplysin was able to target metabolic activity of the prostate cancer cells, without disrupting cell membrane's integrity and had a wide therapeutic window amongst the fascaplysin alkaloids.
