Aminin D.L., Gorpenchenko T.Y., Bulgakov V.P., Andryjashchenko P.V., Avilov S.A., Kalinin V.I.
В журнале Journal of Medicinal Food
Год: 2011 Том: 14 Номер: 6 Страницы: 594-600
Holothurian triterpene glycosides are known to possess multiple biological activities. Here we show that cucumarioside A2-2 from the Far-Eastern edible holothurian Cucumaria japonica possesses potent immunomodulatory properties. The present studies were done to determine if cucumarioside A 2-2 would affect macrophage adhesion, spreading, and motility. Resident peritoneal macrophages, collected from BALB/c mice, were exposed in vitro to low concentrations of cucumarioside A2-2 and compared with appropriate controls. Results indicate that 0.02μg/mL cucumarioside A 2-2 significantly enhanced macrophage morphology parameters and behavior. The glycoside stimulated these parameters by increasing the number of cells with increased adhesion properties as well as the spreading reaction and motility velocity by at least almost twofold. The data are discussed in terms of possible mechanisms underlying the immunomodulatory properties of cucumarioside A2-2. © Copyright 2011, Mary Ann Liebert, Inc.
