Koldaev V.M.
Международный журнал прикладных и фундаментальных исследований 2025; (5): 25-29
Chlorophylls, green pigments of plants, exhibit antioxidant activity and reduce the risk of metabolic disorders during oxidative stress in humans and animals. The aim of the work was to analyze publications on the therapeutic and prophylactic capabilities of chlorophylls. A search was conducted in the bibliographic databases Web of Science, Scopus, Medline, Google Scholar, Library for the most valid publications on the use of chlorophylls in oncology, obesity and neurodegeneration over the past 10 years. The conducted analysis showed that the therapeutic and prophylactic effects of chlorophyll and its derivatives are mainly due to their antioxidant properties, while the correction of the consequences of oxidative stress can be used to prevent abdominal obesity, and chlorophyll-induced apoptosis of cancer cells to reduce the risk of carcinogenesis. Chlorophylls alleviate the symptoms of dementia by reducing the effects of oxidative stress, which is the main factor in the genesis of damage to brain neurons. At the same time, the dosages of chlorophylls have not been sufficiently developed and there are no comparisons of the therapeutic effects with known drugs. The wide introduction of chlorophylls into medical practice is hampered by their high lability and degradation under the influence of technological factors. Future research should be aimed at developing stable chlorophyll-containing phytopreparations with determination of pharmacodynamic parameters.
