Roslik G.V., Kartavtseva I.V., Kosoy M.Y.
A.I.Kurentsov memorial lectures 2024; (35): 172-182
The Korean field mouse (Apodemus peninsulae) is the main host of the Amur orthohantavirus, a strain of hantaviruses responsible for hemorrhagic fever with renal syndrome (HFRS). The virus was identified in one laboratory and three natural populations of A. peninsulae from the Primorsky Krai. Analysis of the variability in B chromosome numbers and morphotypes showed a number of common characteristics in all individuals with HFRS+. They had low numbers of B chromosomes (1, 2 or 0) and their DNA mass indexes (mB indexes), elimination of B chromosomes (negative values of the accumulation coefficient A), absence of mosaicism and a decrease in morphotypic diversity in the virus reservoirs and in the studied natural populations within the Primorsky Krai. It was suggested that reduced variability of B chromosomes may affect a decrease in adaptive capabilities of their natural rodent reservoirs. There is probably a connection between a decrease in the number and diversity of B chromosome morphotypes of A. peninsulae and carriage of the Amur orthohantavirus. However, studying this issue requires further collaboration with virologists.
