Holothurian triterpene glycoside cucumarioside A2-2 induces macrophages activation and polarization in cancer immunotherapy

Chuang W.H., Pislyagin E., Lin L.Y., Menchinskaya E., Chernikov O., Kozhemyako V., Gorpenchenko T., Manzhulo I., Chaikina E., Agafonova I., Silchenko A., Avilov S., Stonik V., Tzou Sh.C., Aminin D., Wang Y.M.

Cancer Cell International 2023; 23: 292

Despite intensive developments of adoptive T cell and NK cell therapies, the efficacy against solid tumors remains elusive. Our study demonstrates that macrophage-based cell therapy could be a potent therapeutic option against solid tumors.

DOI 10.1186/s12935-023-03141-z

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