Plaksen N.V., Ustinova L.V., Stepanov S.V., Ponomarchuk S.G., Salikova A.A., Stepacheva O.M., Manyakhin A.Y.
Дальневосточный медицинский журнал 2022; (2): 51-56
The development of a new herbal medicinal product requires determination of its composition and safety. The content of the sum of extracted substances and flavonoids was determined according to the method proposed by the State Pharmacopoeia of the XIV edition. No acute toxicity was detected when the Empetrum nigrum extract was injected through a probe in doses from 60 mg / 20 g to 110 mg / 20 g, LD50 was not revealed. Empetrum nigrum herb extract according to GOST 12.1.007-76 is classified as low-risk substance. Abstract deviations of standard indicators of biochemical and clinical analyzes with the introduction of Empetrum nigrum extract at a maximum dose for 30 days were within normal limits.
